Er Zhi Wan - 二至丸 - Two Solstice Pill

English:	Two-Solstice Pill
Also Known As:	Two Ultimate Pill Two Supreme Pill

Herbs And Actions

Pharmaceutical Latin	Pin Yin	Dosage	Actions
Fr. Ligustri Lucidi	Nu Zhen Zi	500g	Nourishes and tonifies the Liver and Kidney Yin, clears Deficiency Heat and improves vision. With Mo Han Lian, strengthens the Yin to blacken the hair.
Hb. Ecliptae	Han Lian Cao	500g	Nourishes and tonifies the Liver and Kidney Yin, cools the Blood and stops bleeding. With Nu Zhen Zi, for dizziness, blurred vision, and premature graying of the hair due to severe Liver and Kidney Yin Deficiency with ascendant Yang.

Formula Actions

• Nourishes Kidney and Liver Yin and Blood

Syndromes

• Kidney and Liver Yin Deficiency
• Kidney & Liver Yin deficiency (Secondary source)

Clinical Manifestations

Weak and sore lower back and knees Weakness and atrophy of the legs Dry, parched mouth and throat Dizziness Blurred vision Insomnia Dream disturbed sleep Spermatorrhea

Prematurely gray hair Premature hair loss A bitter taste in the mouth Nocturnal emissions Hypermenorrhea T: Red and dry C: Little or None P: Thready and rapid Irritability

Treats

Insomnia Hepatitis B Threatened miscarriage Hemorrhage Hemoptysis Hematochezia Obesity Tourette syndrome Premature ovarian failure, prevention Coronary Heart disease Neurasthenia Dizziness Spermatorrhea Metrorrhagia Painful obstruction

Chronic nephritis Aplastic anemia Neurasthenia Palpitations Menorrhagia Hematuria Prostatitis Prolonged menstruation Alopecia Hyperglycemia Lumbago Nocturnal emissions Constipation Post-menopausal uterine bleeding Prematurely gray hair

Contraindications And Herb/Drug Interactions

Notes

• This formula can replace Six Ingredient Pill with Rehmannia Liu Wei Di Huang Wan, especially when chronic bleeding is manifest.
• Composition: Nu Zhen Zi 7.5g, Han Lian Cao 7.5g (Secondary source)
• The source text says Nu Zhen Zi should be harvested at the winter solstice and Han Lian Cao at the summer solstice, hence the name.

Modifications

For a stronger effect:		For chronic nephritis due to Liver and Kidney Yin Deficiency with Heat in the Blood:
+ Fr. Mori	Sang Shen	+ Lycium Fruit, Chrysanthemum and Rehmannia Pill Qi Ju Di Huang Wan
For chronic nephritis due to Liver and Kidney Yin Deficiency with Heat in the Blood and severe Yin Deficiency:		For chronic nephritis due to Liver and Kidney Yin Deficiency with Heat in the Blood and Liver Yang Rising:
+ Lycium Fruit, Chrysanthemum and Rehmannia Pill Qi Ju Di Huang Wan		+ Lycium Fruit, Chrysanthemum and Rehmannia Pill Qi Ju Di Huang Wan
+ Plastrum Testudinis	Gui Ban	+ Rx. Gentianae	Long Dan Cao
+ Rx. Ophiopogonis	Mai Men Dong	+ Sp. Prunellae	Xia Ku Cao
For chronic nephritis due to Liver and Kidney Yin and Yang Deficiency with Heat in the Blood:		For aplastic anemia due to Qi and Yin Deficiency:
+ Lycium Fruit, Chrysanthemum and Rehmannia Pill Qi Ju Di Huang Wan		+ Rx. Ginseng	Ren Shen
+ Rz. Curculiginis	Xian Mao	+ Colla Corii Asini	E Jiao
+ Hb. Epimedii	Yin Yang Huo	+ Rx. Astragali	Huang Qi
For aplastic anemia due to Kidney and Liver Yin Deficiency:		For hepatitis B with Damp-Heat:
+ Rx. Rehmanniae Preparata	Shu Di Huang	+ Hb. Artemisiae Scopariae	Yin Chen Hao
+ Sm. Cuscutae	Tu Si Zi	+ Rz. Smilacis Glabrae	Tu Fu Ling
+ Rx. Angelicae Sinensis	Dang Gui	+ Hb. Sedi	Chui Pen Cao
+ Qi tonics if necessary		For hepatitis B with Heat:
For hepatitis B with a poor appetite:		+ Rx. Isatidis	Ban Lan Gen
+ Processed Endothelium Corneum Gigeriae Galli	Ji Nei Jin	+ Hb. Taraxaci	Pu Gong Ying
+ Dry-Fried Fr. Oryzae Germinatus	Gu Ya	For hepatitis B with constipation:
For threatened miscarriage:		+ Processed Rx. et Rz. Rhei	Da Huang
+ Cx. Eucommiae	Du Zhong	+ Rz. Polygoni Cuspidati	Hu Zhang
+ Hb. Taxilli	Sang Ji Sheng	For threatened miscarriage with Qi Deficiency:
+ Hb. Agastaches	Huo Xiang	+ Cx. Eucommiae	Du Zhong
+ Caul. Perillae	Zi Su Geng	+ Hb. Taxilli	Sang Ji Sheng
+ Cornu Cervi Degelatinatum	Lu Jiao Shuang	+ Hb. Agastaches	Huo Xiang
For threatened miscarriage with Yang Deficiency:		+ Caul. Perillae	Zi Su Geng
+ Cx. Eucommiae	Du Zhong	+ Cornu Cervi Degelatinatum	Lu Jiao Shuang
+ Hb. Taxilli	Sang Ji Sheng	+ Rx. Pseudostellariae	Tai Zi Shen
+ Hb. Agastaches	Huo Xiang	+ Rx. Astragali	Huang Qi
+ Caul. Perillae	Zi Su Geng	For threatened miscarriage with Yin Deficiency:
+ Cornu Cervi Degelatinatum	Lu Jiao Shuang	+ Cx. Eucommiae	Du Zhong
For threatened miscarriage with Blood Deficiency:		+ Hb. Taxilli	Sang Ji Sheng
+ Cx. Eucommiae	Du Zhong	+ Hb. Agastaches	Huo Xiang
+ Hb. Taxilli	Sang Ji Sheng	+ Caul. Perillae	Zi Su Geng
+ Hb. Agastaches	Huo Xiang	+ Cornu Cervi Degelatinatum	Lu Jiao Shuang
+ Caul. Perillae	Zi Su Geng	+ Rx. Rehmanniae	Sheng Di Huang
+ Cornu Cervi Degelatinatum	Lu Jiao Shuang	+ Fol. Mori	Sang Ye
+ Fr. Lycii	Gou Qi Zi	+ Rx. Scutellariae	Huang Qin
+ Testa Glycinis	Lu Dou Yi	+ Caul Bambusae in Taeniam	Zhu Ru
For threatened miscarriage with Qi Stagnation:		For threatened miscarriage with profuse bleeding:
+ Cx. Eucommiae	Du Zhong	+ Cx. Eucommiae	Du Zhong
+ Hb. Taxilli	Sang Ji Sheng	+ Hb. Taxilli	Sang Ji Sheng
+ Hb. Agastaches	Huo Xiang	+ Hb. Agastaches	Huo Xiang
+ Caul. Perillae	Zi Su Geng	+ Caul. Perillae	Zi Su Geng
+ Cornu Cervi Degelatinatum	Lu Jiao Shuang	+ Cornu Cervi Degelatinatum	Lu Jiao Shuang
+ Rx. Aucklandiae	Mu Xiang	+ Calcined Fossilia Ossis Mastodi	Duan Long Gu
+ Fr. Amomi	Sha Ren	+ Concha Ostreae	Mu Li
For threatened miscarriage with constipation and dry stool:		+ Crinis Carbonisatus	Xue Yu Tan
+ Cx. Eucommiae	Du Zhong	For prostatitis:
+ Hb. Taxilli	Sang Ji Sheng	+ Six Ingredient Pill with Rehmannia Liu Wei Di Huang Wan
+ Hb. Agastaches	Huo Xiang
+ Caul. Perillae	Zi Su Geng	+ 9g Rx. Rehmanniae	Sheng Di Huang
+ Cornu Cervi Degelatinatum	Lu Jiao Shuang	+ 9g Rz. Smilacis Glabrae	Tu Fu ling
+ Rx. Scrophulariae	Xuan Shen	+ 9g Rz. Dioscoreae Hypoglaucae	Bei Xie
+ Sm. Cannabis	Huo Ma Ren
+ Rx. Peucedani	Qian Hu	For prostatitis with nocturia and seminal emission
For prostatitis with Qi Deficiency:
+ Six Ingredient Pill with Rehmannia Liu Wei Di Huang Wan		+ Six Ingredient Pill with Rehmannia Liu Wei Di Huang Wan
+ 9g Rx. Rehmanniae	Sheng Di Huang	+ 9g Rx. Rehmanniae	Sheng Di Huang
+ 9g Rz. Smilacis Glabrae	Tu Fu ling	+ 9g Rz. Smilacis Glabrae	Tu Fu ling
+ 9g Rz. Dioscoreae Hypoglaucae	Bei Xie	+ 9g Rz. Dioscoreae Hypoglaucae	Bei Xie
+ 15g Rx. Astragali	Huang Qi	+ 12g Fr. Rosae Laevigatae	Jin Ying Zi
+ 9g Rz. Atractylodis Macrocephalae	Bai Zhu
+ 12g Sm. Euryales	Qian Shi
For prostatitis with nodules on the prostate gland:		+12g Fr. Schisandrae	Wu Wei Zi
+ Six Ingredient Pill with Rehmannia Liu Wei Di Huang Wan		For prostatitis with Kidney Yang Deficiency:
+ Six Ingredient Pill with Rehmannia Liu Wei Di Huang Wan
+ 9g Rx. Rehmanniae	Sheng Di Huang
+ 9g Rz. Smilacis Glabrae	Tu Fu ling	+ 9g Rx. Rehmanniae	Sheng Di Huang
+ 9g Rz. Smilacis Glabrae	Tu Fu ling
+ 9g Rz. Dioscoreae Hypoglaucae	Bei Xie
+ 9g Rz. Dioscoreae Hypoglaucae	Bei Xie
+ 12g Sm. Litchi	Li Zhi He
+ 12g Sm. Citri Reticulatae	Ju He	+ 1g Cx. Cinnamomi	Rou Gui
+ 12g Hb. Epimedii	Yin Yang Huo
+ 12g Endothelium Corneum Gigeriae Galli	Ji Nei Jin	+12g Hb. Morindae Officinalis	Ba Ji Tian
For prostatitis with difficult urination and a burning sensation:		For prostatitis with restlessness and insomnia:
+ Six Ingredient Pill with Rehmannia Liu Wei Di Huang Wan
+ Six Ingredient Pill with Rehmannia Liu Wei Di Huang Wan
+ 9g Rx. Rehmanniae	Sheng Di Huang	+ 9g Rx. Rehmanniae	Sheng Di Huang
+ 9g Rz. Smilacis Glabrae	Tu Fu ling	+ 9g Rz. Smilacis Glabrae	Tu Fu ling
+ 9g Rz. Dioscoreae Hypoglaucae	Bei Xie	+ 9g Rz. Dioscoreae Hypoglaucae	Bei Xie
+ 15g Sm. Plantaginis	Che Qian Zi	+ 9g Rx. Rehmanniae	Sheng Di Huang
For menopause syndrome due to Kidney and Liver Yin Deficiency with Liver Yang Rising:		+ 12g Rx. Polygalae	Yuan Zhi
+12g Rx. Acori Tatarinowii	Shi Chang Pu
+ Restore the Left (Kidney) Drink Zuo Gui Yin
+ 12g Poria Pararadicis	Fu Shen
+ 20g Concha Haliotidis	Shi Jue Ming	For Infertility:
+ 15g Rz. Curcumae	Yu Jin	+ Nourishing the Essence and Growing Jade Decoction Yang Jing Zhong Yu Tang
+ 15g Rx. Paeoniae Alba	Bai Shao
For infertility due to Deficiency Fire Blazing with emaciation, five sole Heat and recurrent fever in the afternoon		For Infertility with insufficient Blood and decreased menses that are light in color:
+ Nourishing the Essence and Growing Jade Decoction Yang Jing Zhong Yu Tang		+ Nourishing the Essence and Growing Jade Decoction Yang Jing Zhong Yu Tang
+ 12g Cx. Moutan	Mu Dan Pi	+ 10g Colla Cervi Cornus	Lu Jiao Jiao
+ 12g Cx. Lycii	Di Gu Pi	+ 10g Placenta Hominis	Zi He Che
+ 10g Cx. Phellodendri	Huang Bai	Other Blood Tonics may be added
+ 20g Plastrum Testudinis	Gui Ban	For Tourette syndrome:
+ Major Arrest Wind Pearl. Da Ding Feng Zhu
For prolonged menstruation:
+Two Di Decoction Liang Di Tang		For prevention of premature ovarian failure due to Kidney and Heart Failure to Communicate :
For alopecia:		+ Coptis and Ass-Hide Gelatin Decoction Huang Lian E Jiao Tang
+ Restore the Left (Kidney) Drink Zuo Gui Yin
+ Restore the Kidneys Pill Gui Shen Wan
+ Rx. 30g Polygoni Multiflori Preparata	Zhi He Shou Wu
For coronary Heart disease due to Heart and Kidney Yin Deficiency:
+ 30g Placenta Hominis	Zi He Che	+ Linking Decoction Yi Guan Jian
+ 30g Colla Corii Asini	E Jiao
For coronary Heart disease due to Heart and Kidney Yin Deficiency with severe pain:		+ 12g Rx. Salviae Miltiorrhizae	Dan Shen
+ Linking Decoction Yi Guan Jian		+ 9g Cx. Moutan	Mu Dan Pi
9g Rx. Cyathulae	Chuan Niu Xi
+ 12g Rx. Salviae Miltiorrhizae	Dan Shen	+ 15g Concha Ostreae	Mu Li
For coronary Heart disease due to Heart and Kidney Yin Deficiency with severe night sweats:
+ 9g Cx. Moutan	Mu Dan Pi	+ Linking Decoction Yi Guan Jian
9g Rx. Cyathulae	Chuan Niu Xi
+ 15g Concha Ostreae	Mu Li	+ 12g Rx. Salviae Miltiorrhizae	Dan Shen
+ 6g Lignum Aquilariae Resinatum	Chen Xiang
+ 9g Cx. Moutan	Mu Dan Pi
+ 9g Rz. Chuanxiong	Chuan Xiong	9g Rx. Cyathulae	Chuan Niu Xi
For coronary Heart disease due to Heart and Kidney Yin Deficiency with severe palpitations and insomnia:		+ 15g Concha Ostreae	Mu Li
+9g Rz. Anemarrhenae	Zhi Mu
+ Linking Decoction Yi Guan Jian		+ 9g Cx. Phellodendri	Huang Bai
+ 9g Cx. Lycii	Di Gu Pi
+ 12g Rx. Salviae Miltiorrhizae	Dan Shen	For coronary Heart disease due to Heart and Kidney Yin Deficiency with high-pitched tinnitus:
+ 9g Cx. Moutan	Mu Dan Pi	+ Linking Decoction Yi Guan Jian
9g Rx. Cyathulae	Chuan Niu Xi
+ 15g Concha Ostreae	Mu Li	+ 12g Rx. Salviae Miltiorrhizae	Dan Shen
+ 9g Sm. Zizyphi Spinosae	Suan Zao Ren
+ 9g Cx. Moutan	Mu Dan Pi
+ 9g Sm. Platycladi	Bai Zi Ren	9g Rx. Cyathulae	Chuan Niu Xi
For coronary Heart disease due to Heart and Kidney Yin Deficiency with high-pitched tinnitus:		+ 15g Concha Ostreae	Mu Li
+ 15g Concha Haliotidis	Shi Jue Ming
+ Linking Decoction Yi Guan Jian		+ 9g Ram. cum Uncis Uncariae	Gou Teng
+ 12g Rx. Salviae Miltiorrhizae	Dan Shen	For fibrocystic breast disease due to Disharmony between the Chong and Ren:
+ Rambling Powder Xiao Yao San
+ 9g Cx. Moutan	Mu Dan Pi
9g Rx. Cyathulae	Chuan Niu Xi
+ 15g Concha Ostreae	Mu Li	+ Two Immortals Decoction Er Xian Tang
+ 9g Rx. Codonopsis	Dang Shen
+ 6g Rx. Glycyrrhizae Preparata	Zhi Gan Cao	For fibrocystic breast disease due to Disharmony between the Chong and Ren with hard nodules:
For fibrocystic breast disease due to Disharmony between the Chong and Ren with nipple discharge:		+ Rambling Powder Xiao Yao San
+ Two Immortals Decoction Er Xian Tang
+ Rambling Powder Xiao Yao San
+ Rz. Curcumae	Yu Jin
+ Two Immortals Decoction Er Xian Tang		+ Rz. Sparganii	E Zhu
+ Sargassum	Hai Zao
+ Cx. Moutan	Mu Dan Pi	For post-menopausal uterine bleeding with anxiety, a quick temper, hypochondriac pain, a bitter taste, a red face, fever, perspiration and emotional changes:
+ Fr. Gardeniae	Zhi Zi
+ Hb. Ecliptae	Han Lian Cao
For post-menopausal uterine bleeding due to Kidney Yin and Yang Deficiency:		+ Plastrum Testudinis	Gui Ban
+ Rx. Curcumae	Yu Jin
+ Restore the Left Drink Zuo Gui Yin		For post-menopausal uterine bleeding due to Kidney Yin and Yang Deficiency with insomnia:
+ Rx. Rehmanniae Preparata	Shu Di Huang	+ Restore the Left Drink Zuo Gui Yin
For post-menopausal uterine bleeding due to Kidney Yin and Yang Deficiency with lumbar pain:		+ Rx. Rehmanniae Preparata	Shu Di Huang
+ Restore the Left Drink Zuo Gui Yin		+ Caulis Polygoni Multiflori	Ye Jiao Teng
+ Rx. Rehmanniae Preparata	Shu Di Huang	+ Margarita	Zhen Zhu
+ Rx. Dipsaci	Xu Duan
+ Fr. Psoraliae	Bu Gu Zhi