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Clinical
Manifestations
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- Allergic purpura (AP), a form of vasculitis (inflammation of the blood vessels), is a disease characterized by inflammation of the small arterial vessels (capillaries) in the skin, kidneys, and intestinal tract. Symptoms include:
A purple spotted skin rash
Abdominal pain
Gastrointestinal upsets
Joint inflammation, swelling and pain
- Although the exact cause of the disease is unknown, it often develops following a recent viral or bacterial infection of the respiratory tract and is an abnormal reaction of the immune system to the infection.
- AP may occur suddenly, or it may develop slowly over a period of weeks. The characteristic rash is always present in the disease. The rash begins as areas of redness and as small hives, which may develop anywhere on the body, but especially on the legs and buttocks, and may itch. The rash is caused by inflamed capillaries rupturing, allowing small amounts of blood to accumulate in the surrounding tissues. Through time the rash changes color from red to a bruised, purple color. Each rash spot will last about five days, and the rash can reoccur several times. The skin rash is the most obvious symptom of AP but is not the most serious, for the joints, gastrointestinal tract, and kidneys may also be affected.
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